DR MANISH-2.pdf laser proctology piles and fistula
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Get the best piles and fistula treatment in Jaipur with advanced laser proctology techniques. Dr. Manish Rajput, a renowned specialist, provides painless, quick, and highly effective treatments for piles, fissures, and fistula. Using cutting-edge laser technology, the procedures ensure minimal discomfort, no stitches, and faster recovery, helping patients return to their daily lives with ease. Dr. Rajput is committed to offering personalized care and long-term solutions, ensuring lasting relief and improved quality of life. With his expertise and modern facilities, you can expect safe and reliable treatment for all proctological conditions.
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Streamlining Pharma Logistics A Guide to Good Distribution Practices (GDP).pptxDr. Smita Kumbhar Good Distribution Practices (GDP) are a critical component of quality assurance in the pharmaceutical supply chain, ensuring that medicines are consistently stored, transported, and handled under suitable conditions. Adhering to GDP helps safeguard product quality and protect patients from ineffective or harmful pharmaceuticals. As global commerce expands, harmonized GDP regulations have emerged, supported by WHO, USP, CDSCO, and ISO frameworks. This article explores the legal landscape, principles, operational standards, personnel responsibilities, documentation protocols, premises and equipment norms, delivery and return procedures, self-inspection processes, and the role of stability testing, offering a comprehensive view of the global GDP ecosystem.
1. Introduction to Good Distribution Practices (GDP)
Good Distribution Practices refer to a set of guidelines ensuring that pharmaceutical products are consistently stored, transported, and handled under suitable conditions as required by the marketing authorization or product specification. The concept is closely related to Good Manufacturing Practices (GMP), with a focus on the post-manufacturing phase of the supply chain. GDP encompasses the entire logistical flow from the manufacturer to the final point of supply, ensuring integrity, traceability, and safety of medicinal products.
GDP is essential because any deviation in storage or transport conditions can compromise the product's efficacy and safety. Compliance with GDP minimizes the risks related to contamination, mix-ups, and product degradation, and helps in the identification and recall of defective products.
2. Legal GDP Requirements Worldwide
Various global bodies have established GDP guidelines. In the European Union, the most referenced document is the "Guidelines on Good Distribution Practice of medicinal products for human use" (2013/C 343/01). These guidelines outline specific requirements for personnel, premises, documentation, and transportation.
In the United States, the FDA and the United States Pharmacopeia (USP) provide detailed standards concerning the distribution of pharmaceutical products. USP Chapter <1079> focuses on good storage and shipping practices, particularly for temperature-sensitive products.
WHO provides GDP guidelines applicable to all member states, particularly focusing on developing nations to ensure consistent quality standards. Similarly, India's Central Drugs Standard Control Organization (CDSCO) issues GDP-related rules, focusing on wholesalers, distributors, and transportation services. These regional adaptations serve to align GDP globally while respecting local regulatory and infrastructural capacities.
3. Core Principles of GDP
The foundation of GDP lies in the following principles:
• Ensuring the quality, safety, and efficacy of pharmaceutical products during distribution.
• Full traceability of every product batch throughout the supply chain.
• Preventing counterfeit or substandard medicines
Tracheoesophageal Fistula || TEF || Esophageal fistula
Tracheoesophageal Fistula || TEF || Esophageal fistulaAnurag Joseph 1. Introduction
Defines Tracheoesophageal Fistula (TEF)
Mentions abnormal connection between trachea and esophagus
2. Anatomy of Trachea
Structure and position of the trachea
Relation to esophagus
Length, location (C6 to T4), and composition
3. Anatomy of Esophagus
Structure and function
Layers of the esophagus
Developmental position behind trachea
4. Normal Physiology
Swallowing mechanism
Food passage and airway protection
Coordination between respiratory and digestive tracts
5. Embryology of Trachea and Esophagus
Development from foregut
Normal separation into trachea and esophagus during 4th-6th week of gestation
6. Definition of TEF
Clear medical definition
Describes abnormal communication between trachea and esophagus
7. Incidence
TEF incidence: 1 in 3,000 to 4,500 live births
More common in males
8. Etiology (Causes)
Incomplete separation of trachea and esophagus during embryogenesis
Genetic and environmental factors
9. Classification
Types A to E (with diagrams in actual slides)
Most common type: Type C (EA with distal TEF)
10. Pathophysiology
Effects of connection: aspiration, air in stomach
Esophageal atresia leads to feeding difficulty
11. Clinical Manifestations
Excessive salivation, choking, coughing
Cyanosis during feeding
Abdominal distension
12. Diagnostic Evaluation
Inability to pass nasogastric tube
Chest X-ray showing coiled tube
Contrast studies, bronchoscopy
13. Associated Anomalies
VACTERL association: Vertebral, Anorectal, Cardiac, Tracheal, Esophageal, Renal, Limb
14. Management
Preoperative: Stabilization, prevent aspiration
Surgical: Ligation of fistula, esophageal anastomosis
15. Postoperative Care
Respiratory support, feeding via gastrostomy initially
Monitor for leaks, strictures
16. Nursing Diagnosis
Impaired gas exchange, risk for aspiration, imbalanced nutrition
17. Nursing Management
Pre- and post-op care
Positioning, suctioning, feeding support
18. Complications
Anastomotic leak, stricture, recurrent fistula, GERD
19. Prognosis
Good if treated early
Depends on birth weight, associated anomalies
20. Prevention
No absolute prevention
Early prenatal care and diagnosis may help
21. Conclusion
Summary of importance of early diagnosis and treatment
Powering Genomic Workflows with Upgraded Catalogs in VSWarehouse and VarSeq 3
Powering Genomic Workflows with Upgraded Catalogs in VSWarehouse and VarSeq 3Golden Helix As clinical laboratories and genomic research centers process ever-growing volumes of data, the need for robust, scalable, and secure data management solutions has never been greater. The latest upgrades to Catalogs in VSWarehouse and VarSeq 3 deliver a transformative approach to storing, managing, and leveraging genomic and clinical data across on-premises and cloud environments. Join us for an exclusive webcast to explore how these enhanced Catalogs unify technology, boost performance, and introduce fine-grained permissions, empowering organizations to streamline workflows and scale with confidence.
In this session, we will:
- Demonstrate how upgraded Catalogs serve as a flexible backbone for storing genomic records (variants, CNVs, fusions) and clinical support data, seamlessly integrating with VSClinical and VSWarehouse for reusable interpretations
- Showcase new automation features in VarSeq 3, including Saved Exports to Catalogs and Sample Catalog management, replacing legacy file-based processes with dynamic, scalable solutions
- Highlight enterprise-grade security and lifecycle management, with draft-to-publish workflows, role-based permissions, and REST API integration for external systems like EHRs
- Illustrate practical use cases, from custom variant annotations (e.g., blacklisting/whitelisting) to tracking sample analysis progress, all accessible through a browser-based platform
Whether you’re optimizing on-premises deployments or integrating with cloud resources via our Bring Your Own Cloud (BYOC) model, discover how these upgrades provide unmatched control over data, security, and workflow automation. Join us to see how your organization can harness the full potential of Catalogs to drive efficiency, collaboration, and innovation in genomic research and clinical interpretation.
Fertilization and fetal development ppt
Fertilization and fetal development pptKLE's Institute of Nursing Sciences Vidyanagar, Hubballi. Fertilization is the process of fusion of the spermatozoon with the mature ovum. It begins with sperm egg collision and ends with production of mononucleated single cell called the zygote.”
“Fertilization is the process of fusing male gamete, the female gamete, the oocyte to produce the zygote.”
Fetal development is generally divided into three main stages:
1)The germinal (Pre-embryonic) stage : From fertilization to Implantation. (First 14 days or 2 weeks after conception), involves cell division and the formation of the blastocyst.
2)The embryonic stage : From 3rd weeks to 8th weeks, the development of major organ systems.
3)The fetal stage : From 9th week until birth, is characterized by organ maturation, growth spurts, and development of sensory organs and movements.
Understanding Acute and Chronic Renal Failure: Pathophysiology, Etiology, Cli...
Understanding Acute and Chronic Renal Failure: Pathophysiology, Etiology, Cli...Dr Aman Suresh Tharayil This presentation provides a comprehensive overview of Acute Renal Failure (ARF) and Chronic Renal Failure (CRF), covering definitions, causes, pathophysiology, signs and symptoms, and stages of disease progression. It is designed for B.Pharm 2nd semester students, pharmacy educators, and healthcare learners seeking a solid foundation in renal pathophysiology. The slides explore key differences between ARF and CRF, highlighting pre-renal, intra-renal, and post-renal causes, and the progression of chronic renal disease from early decline in renal reserve to end-stage kidney failure. Ideal for use in academic lectures, self-learning, or clinical revision.
Nerve Physiology - Properties of Action Potential
Nerve Physiology - Properties of Action PotentialMedicoseAcademics Learning Objectives:
1. Explain the concept of all or nothing principle in propagation of an action potential
2. Differentiate between absolute and relative refractory periods
3. Explain the effect of hypocalcemia on permeability of sodium channels
4. Distinguish the effects of hyperkalemia, hypercalcemia, and hypoxia on the resting membrane potential & action potential
Introduction to ergonomics Lecturs 1(a).pptx
Introduction to ergonomics Lecturs 1(a).pptxBolan University of Medical and Health Sciences ,Quetta The science of fitting jobs to people, and biomechanics, the study of human movement, are closely related and both important for workplace health and safety. Ergonomics aims to optimize the interaction between humans and their work environment to minimize stress and improve well-being. Biomechanics provides the scientific basis for understanding how human movements and forces affect the body, informing ergonomic interventions to prevent injuries and improve productivity.
Dr Aliya S.M
BUMHS,Qta
Anaemia & Polycythaemia Physiological Basis
Anaemia & Polycythaemia Physiological BasisMedicoseAcademics 📌 Title: Anemia – Types, Causes, Pathophysiology, and Clinical Features | Dr. Faiza
🎓 Presented by: Dr. Faiza
Assistant Professor of Physiology
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
🩸 This presentation is a comprehensive overview of Anemia, designed for medical students and healthcare professionals. It covers:
🔬 Learning Objectives:
Classification of anemias: Microcytic, Macrocytic, Normocytic
Differentiation based on etiology, lab findings, and clinical presentation
Unique features of hereditary and acquired anemias (e.g., thalassemia, sickle cell disease)
Diagnostic approaches and pathophysiological mechanisms
Impact of anemia on circulatory function
An overview of polycythemia vera vs secondary polycythemia
💉 Includes detailed tables, RBC indices, blood picture interpretation, and mnemonics for easier recall.
🧠 Ideal for:
MBBS and BDS students
FCPS Part 1 candidates
Educators revising core physiology
Clinical practitioners updating their concepts
📚 Topics Covered:
Iron Deficiency Anemia
Thalassemia (Alpha & Beta)
Sickle Cell Anemia
Megaloblastic Anemia (Vitamin B12 & Folate)
Aplastic Anemia
Acute Blood Loss
Hemolytic Anemias (Hereditary Spherocytosis, G6PD Deficiency)
Circulatory changes in anemia
Primary & Secondary Polycythemia
advanced soft tissue sarcoma_2025_targeted and immunotherapies
advanced soft tissue sarcoma_2025_targeted and immunotherapiesSameer Rastogi In last decade, soft tissue sarcomas have seen change of landscape in the therapeutic aspect. This presentation deals with the recent advances worldwide in various sarcomas.
VENTOUSE delivery //operative delivery pptx
VENTOUSE delivery //operative delivery pptxsonia Ventouse is an instrumental device designed to assist delivery by creating a vacuum between it and the fetal scalp .
The pulling force is dragging the cranium while in forceps ,the pulling force is directly transmitted to the base of the skull
Vacuum extractor consists of
A specially designed cup with a diameter of 30mm, 40mm, 50mm and 60 mm
A rubber attaching the cup to a glass bottle with a screw in between to release the negative pressure
A manometer fitted in the mouth of the glass
Another rubber tube connecting the bottle to a suction piece which may be manual or electronic creating a negative pressure
Introduction to the Physiology of Central Nervous System
Introduction to the Physiology of Central Nervous SystemMedicoseAcademics Learning Objectives:
1. Describe the functional organization of the nervous system
2. Briefly overview the functions of the brain
3. Classify different types of neurons
4. Describe the functions of different types of neuroglial cells
Biophysics Thermodynamics 1 Chapter Notes
Biophysics Thermodynamics 1 Chapter NotesPKLI-Institute of Nursing and Allied Health Sciences Lahore , Pakistan.
Biomechanics of cervical Spine by susan.j (1).ppt
Biomechanics of cervical Spine by susan.j (1).pptBolan University of Medical and Health Sciences ,Quetta
Understanding Acute and Chronic Renal Failure: Pathophysiology, Etiology, Cli...
Understanding Acute and Chronic Renal Failure: Pathophysiology, Etiology, Cli...Dr Aman Suresh Tharayil